کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2014021 | 1067140 | 2009 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The effects of midazolam on the acquisition and expression of fructose- and maltodextrin-based flavour preferences
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
The effects of the benzodiazepine agonist midazolam on the acquisition and expression of flavour preferences were investigated. Rats (Experiment 1) were given one-bottle training with one flavoured solution (CS+) mixed with either fructose or maltodextrin and another solution (CSâ) presented alone. Animals receiving 1Â mg/kg midazolam during training consumed more CSâ than did animals receiving vehicle injections although there was no drug effect on CS+ consumption. In two-bottle tests the CS+ was preferred to the CSâ with the preference being larger in fructose trained animals. Midazolam (0.3-3Â mg/kg) increased total intake but not CS+ preference. Training under midazolam reduced the CS+ preference when fructose, but not maltodextrin, was the reinforcer. In Experiment 2 training consumption was restricted to 10Â ml/session. This removed the difference in CS+ preference between reinforcer types but otherwise the results were as in Experiment 1. The midazolam induced attenuation of fructose-based preferences might reflect an increase in CSâ palatability during training which would reduce the difference between the reinforced and non-reinforced solutions. As maltodextrin supports preferences due to post-ingestive effects manipulation of palatability should be ineffective. Midazolam does not influence the expression of conditioned flavour preferences despite prior evidence that benzodiazepine agonists enhance palatability.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 91, Issue 4, February 2009, Pages 503-510
Journal: Pharmacology Biochemistry and Behavior - Volume 91, Issue 4, February 2009, Pages 503-510
نویسندگان
Dominic M. Dwyer,