کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2014095 | 1067143 | 2007 | 11 صفحه PDF | دانلود رایگان |
We reported previously that social stressors in adolescence (SS: one-hour isolation and new cage partners daily for 16 days) increased locomotor activity to nicotine and to amphetamine in females, but not in males, when tested as adults. Here, we investigated whether effects of stressors in adolescence on locomotor responses to nicotine would be observed in both sexes if tested closer in time to the stressor exposure. We also tested whether social instability was necessary to alter nicotine′s effects on locomotor activity by including a group that underwent daily isolation but was housed with the same partner (ISO). The locomotor-activating effects of nicotine were lower in SS rats compared to ISO and non-stressed control rats. In males, but not in females, there were effects of nicotine treatment and of stress condition on Fos immunoreactive (Fos-ir) cell counts in the paraventricular nucleus (PVN) of the hypothalamus: SS males had higher Fos-ir counts than did ISO and non-stressed control males, and higher Fos-ir counts in the PVN were found in repeated-nicotine groups than in acute-nicotine and saline groups. These results add to evidence that adolescents are uniquely vulnerable to stressors due to ongoing brain development, and also indicate that effects are sex- and stressor-specific.
Journal: Pharmacology Biochemistry and Behavior - Volume 86, Issue 1, January 2007, Pages 92–102