کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2014502 | 1067161 | 2006 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of osemozotan, ritanserin and azasetron on cocaine-induced behavioral sensitization in mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effects of osemozotan, ritanserin and azasetron on cocaine-induced behavioral sensitization in mice Effects of osemozotan, ritanserin and azasetron on cocaine-induced behavioral sensitization in mice](/preview/png/2014502.png)
چکیده انگلیسی
Repeated intermittent administration of psychostimulants causes behavioral sensitization in rodents. Previous studies using serotonin (5-HT) receptor ligands show that the 5-HT system is involved in cocaine-induced behavioral sensitization in rats, but the role of the 5-HT system has not been studied in mice. The present study examined the effects of the 5-HT1A receptor agonist osemozotan, the 5-HT2 receptor antagonist ritanserin and the 5-HT3 receptor antagonist azasetron on cocaine-induced behavioral sensitization in male ddY mice. Repeated administration of cocaine for 7Â days enhanced cocaine-induced locomotor activity, and this sensitization was observed even after withdrawal for 7-14Â days. Cocaine-induced behavioral sensitization after a 7-day withdrawal was significantly reduced with the coadministration of osemozotan, ritanserin or azasetron with cocaine repeatedly for 7Â days. A single injection of osemozotan or ritanserin before cocaine challenge also reduced repeated cocaine-induced behavioral sensitization. However, none of these ligands inhibited cocaine-induced behavioral sensitization, when each drug was administered for 7Â days after repeated cocaine administration. These results suggest that the central 5-HT system plays a role in the development and expression, but not maintenance, of behavioral sensitization in cocaine-treated mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 85, Issue 1, September 2006, Pages 198-205
Journal: Pharmacology Biochemistry and Behavior - Volume 85, Issue 1, September 2006, Pages 198-205
نویسندگان
Yukio Ago, Shigeo Nakamura, Aiko Hayashi, Soichi Itoh, Akemichi Baba, Toshio Matsuda,