Thermodynamic analysis for solid–liquid equilibrium of mercaptosuccinic acid in a binary solvent of methanol and ethyl acetate at temperatures between (278.15 and 333.15) K

• Solubility data of mercaptosuccinic acid in a binary system of methanol and ethyl acetate from 278.15 to 333.15 K were measured.
• The solubility varies with the composition of the solvent and temperature.
• The measured data were regressed with modified Apelblat, CNIBS/R–K and Jouyban–Acree models.
• The thermodynamic properties of dissolution were calculated using van’t Hoff equation and Gibbs equation.
• The dissolution of mercaptosuccinic acid in a binary system of methanol and ethyl acetate is endothermic and spontaneous process.

Data on corresponding solid–liquid equilibrium of mercaptosuccinic acid is essential for a preliminary study of industrial applications. In this paper, we focused on solubility and solution thermodynamics of mercaptosuccinic acid. By gravimetric method, the solid–liquid equilibrium of mercaptosuccinic acid was measured in (methanol + ethyl acetate) binary solvent mixtures from 278.15 K to 333.15 K under atmosphere pressure. The solubility data were then modeled using modified Apelblat equation, a variant of the combined nearly ideal binary solvent/Redich–Kister (CNIBS/R–K) model and Jouyban–Acree model. Computational results showed that the modified Apelblat equation and CNIBS/R–K model have the low MD (mean deviation). In addition, the thermodynamic properties of the solution process, including the Gibbs energy, enthalpy, and entropy were calculated by the van’t Hoff analysis.

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