کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2018929 | 1068356 | 2015 | 18 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Comprehensive analysis of translational osteochondral repair: Focus on the histological assessment
ترجمه فارسی عنوان
تجزیه و تحلیل جامع از ترجمه استئوآرتریتیک: تمرکز بر ارزیابی بافت شناسی
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Articular cartilage guarantees for an optimal functioning of diarthrodial joints by providing a gliding surface for smooth articulation, weight distribution, and shock absorbing while the subchondral bone plays a crucial role in its biomechanical and nutritive support. Both tissues together form the osteochondral unit. The structural assessment of the osteochondral unit is now considered the key standard procedure for evaluating articular cartilage repair in translational animal models. The aim of this review is to give a detailed overview of the different methods for a comprehensive evaluation of osteochondral repair. The main focus is on the histological assessment as the gold standard, together with immunohistochemistry, and polarized light microscopy. Additionally, standards of macroscopic, non-destructive imaging such as high resolution MRI and micro-CT, biochemical, and molecular biological evaluations are addressed. Potential pitfalls of analysis are outlined. A second focus is to suggest recommendations for osteochondral evaluation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Histochemistry and Cytochemistry - Volume 50, Issue 3, October 2015, Pages 19-36
Journal: Progress in Histochemistry and Cytochemistry - Volume 50, Issue 3, October 2015, Pages 19-36
نویسندگان
Patrick Orth, Carolin Peifer, Lars Goebel, Magali Cucchiarini, Henning Madry,