کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2019012 1068381 2011 48 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Taking organelles apart, putting them back together and creating new ones: Lessons from the endoplasmic reticulum
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Taking organelles apart, putting them back together and creating new ones: Lessons from the endoplasmic reticulum
چکیده انگلیسی

The endoplasmic reticulum (ER) is a highly dynamic organelle. It is composed of four subcompartments including nuclear envelope (NE), rough ER (rER), smooth ER (sER) and transitional ER (tER). The subcompartments are interconnected, can fragment and dissociate and are able to reassemble again. They coordinate with cell function by way of protein regulators in the surrounding cytosol. The activity of the many associated molecular machines of the ER as well as the fluid nature of the limiting membrane of the ER contribute extensively to the dynamics of the ER. This review examines the properties of the ER that permit its isolation and purification and the physiological conditions that permit reconstitution both in vitro and in vivo in normal and in disease conditions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Histochemistry and Cytochemistry - Volume 46, Issue 1, June 2011, Pages 1–48
نویسندگان
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