Epoxyeicosatrienoic acids, 20-hydroxyeicosatetraenoic acid, and renal microvascular function

► 20-HETE constricts afferent arterioles and contributes to autoregulation. ► EETs dilate afferent arterioles and act as an EDHF. ► 20-HETE and EETs contribute to purinergic receptor afferent arteriolar responses. ► Soluble epoxide hydrolase, EETs, and 20-HETE are therapeutic targets.