Activation of PPARα by bezafibrate negatively affects de novo synthesis of sphingolipids in regenerating rat liver

▶ Serine palmitoyltransferase (SPT) is a key enzyme in de novo sphingolipid biosynthesis. ▶ Partial hepatectomy and liver regeneration stimulates SPT activity. ▶ PPARα activation decreases protein expression and activity of SPT in regenerating rat liver. ▶ Plasma NEFA and liver sphinganine content decreased in the groups treated with PPARα agonist. ▶ PPARα activation inhibits de novo sphingolipid synthesis by decreasing availability of fatty acids.