کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2019733 1542236 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prostaglandin E2 synthases in neurologic homeostasis and disease
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Prostaglandin E2 synthases in neurologic homeostasis and disease
چکیده انگلیسی

Prostaglandin E2 synthases (PGES) currently comprise a group of three structurally and biologically distinct molecules. These enzymes are part of an important and complex paracrine signaling system involved in a wide range of biological processes. This review focuses on the normal physiological and pathological roles of these enzymes in the nervous system. Specific topics include the role of PGES(s) in fever and sickness behavior, inflammatory pain, and neural disease. Although the field is in its early stages, ongoing development of selective PGES inhibitors for possible use in people creates a significant need for more fully understanding the biological roles of these important enzymes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Prostaglandins & Other Lipid Mediators - Volume 91, Issues 3–4, April 2010, Pages 113–117
نویسندگان
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