Evidence suggesting multiple promoting roles of luteal group IVA phospholipase A2 in prostaglandin F2α-induced regression in pseudopregnant rats

▶ A GIVA PLA2 inhibitor tends to inhibit PGF2a-induced functional luteolysis. ▶ The inhibitor inhibit luteal cell apoptosis induced in vivo and in vitro. ▶ The inhibitor reduces macrophage infiltration in corpus luteum. ▶ The GIVA PLA2 inhibitor is more potent than COX-1 and -2 inhibitors.