Variability in the response to antiplatelet treatment in diabetes mellitus

► The hyperreactive platelet phenotype plays a key role in diabetic atherothrombosis. ► The efficacy of antiplatelet therapy for primary prevention in this setting is uncertain. ► Residual platelet activity despite antiplatelet treatment has been reported in diabetics. ► The determinants of interindividual variability in response to antiplatelet drugs are reviewed.