The pulmonary pharmacology of [4-methoxy-N1-(4-trans-nitrooxycyclohexyl)-N3-(3-pyridinylmethyl)-1,3-benzenedicarboxamide] (2NTX-99), an anti-atherotrombotic compound with therapeutic potential in pathological conditions that target lung vasculature

► 2NTX-99 was tested in vitro in pulmonary vasculature and central-peripheral airways. ► TXA2 analogue-increased vessel tone was reduced by 2NTX-99. ► 2NTX-99 vasodilated the pulmonary vasculature via the release of NO. ► combined activity of 2NTX-99 as NO-donor and TXA2 synthesis inhibitor was shown. ► 2NTX-99 has potential therapeutic use in pathologies of the pulmonary vascular bed.