کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2019921 1542249 2007 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Urinary prostaglandin E2 in the newborn and infant
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Urinary prostaglandin E2 in the newborn and infant
چکیده انگلیسی
Prostaglandin E2 (PGE2) belongs to a family of biologically active lipids derived from the 20-carbon essential fatty acids. Renal PGE2 is involved in the development of the kidney; it also contributes to regulate renal perfusion and glomerular filtration rate, and controls water and electrolyte balance. Furthermore, this mediator protects the kidney against excessive functional changes during the transition from fetal to extrauterine life, when it counteracts the vasoconstrictive effects of high levels of angiotensin II and other mediators. There is evidence that PGE2 plays an important pathophysiological role in neonatal conditions of renal stress, and in congenital or acquired nephropaties. Thus, measurement of urinary PGE2 as an index of renal synthesis of this primary prostaglandin may represent a non-invasive and sensitive method of investigating the homeostatic function of the kidney in early life. The aim of this literature review is to examine urinary PGE2 as a non-invasive marker of renal homeostasis in the newborn and infant under both physiological and pathological conditions, or during treatments with widely used, potentially toxic drugs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Prostaglandins & Other Lipid Mediators - Volume 84, Issues 1–2, August 2007, Pages 1-13
نویسندگان
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