Thermodynamic solubility of pioglitazone HCl in polyethylene glycols 200, 400 or 600 + water mixtures at 303.2 and 308.2 K—Data report and modeling

• Measuring solubility of pioglitazone HCl in aqueous binary mixtures of PEGs 200, 400 and 600 at 298.2 to 308.2 K.
• Modeling with three kind of cosolvency models: Three different cosolvency models; yalkowsky, Jouyban–Acree and combined version of the Jouyban–Acree model with van’t Hoff approach.
• Comparing the produced error percentages with whole three models.
• Using the trained version for predicting the solubility data.

The solubility of pioglitazone HCl (99 data points) in binary mixtures of polyethylen glycols (PEGs) 200, 400 or 600 + water at three different temperatures which ranged from 298.2 K to 308.2 K were reported. Three different cosolvency models; yalkowsky, Jouyban–Acree and combined version of the Jouyban–Acree model with van’t Hoff approach, have been used for correlating the reported data, and the correlation OMRDs are 65.2%, 18.0% and 17.8% respectively. Also, a previously trained version of the Jouyban–Acree model has been used for predicting these 99 reported data points which the prediction OMRD is 23.4%.