Plasma levels of leptin and orexin A in the restrictive type of anorexia nervosa

► We analyzed leptin and orexin A plasma levels in restrictive type of anorexia nervosa. ► We examined changes in these peptides during 6-month of psychotherapeutic treatment. ► Before the therapy, both leptin and orexin A levels were lower than in control group. ► Leptin levels increased and showed a correlation with BMI. ► Orexin A levels showed further decrease, with no correlation with BMI.