کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2023101 | 1542430 | 2009 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential regulation of urocortins1-3 mRNA in human umbilical vein endothelial cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Urocortins (Ucns) are members of the corticotropin-releasing factor (CRF) family of peptides. Ucns would have potent effects on the cardiovascular system via the CRF receptor type 2 (CRF2 receptor) in the cardiovascular system. However, an endogenous role and regulation of each Ucn have not been determined in the system. In the present study, we extended observations on stress or hormone-induced changes in Ucn gene expression in the cardiovascular system. Human umbilical vein endothelial cells (HUVECs) express Ucn1, Ucn2, and Ucn3 mRNAs, but not CRF mRNA, and the receptor, CRF2α receptor mRNA. Lipopolysaccharides decreased Ucn1 mRNA levels, while it increased Ucn2 and Ucn3 mRNA levels in HUVECs. Interleukin-1β decreased Ucn1 and Ucn2 mRNA levels, while it increased Ucn3 mRNA levels in HUVECs. Forskolin increased Ucn1 mRNA levels, while it decreased Ucn2 and Ucn3 mRNA levels. Ucns1-3 mRNA levels are differentially regulated in HUVECs. Differential regulation of Ucns1-3 mRNA may suggest differential roles of those in HUVECs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Peptides - Volume 155, Issues 1â3, 5 June 2009, Pages 131-138
Journal: Regulatory Peptides - Volume 155, Issues 1â3, 5 June 2009, Pages 131-138
نویسندگان
Kazunori Kageyama, Komaki Hanada, Toshihiro Suda,