کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2023116 | 1542435 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The transcriptional co-activator PGC-1α up regulates apelin in human and mouse adipocytes
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
By using pangenomic microarray, we identified apelin as a unique adipokine up regulated by the transcriptional co-activator peroxisome proliferator-activated receptor γ (PPARγ) co-activator 1α (PGC-1α) in human white adipocytes. We investigated its regulation in vitro and in vivo. Overexpression of PGC-1α by adenovirus in human adipocytes induces apelin expression and secretion. Pharmacological induction of cAMP, an upstream regulator of endogenous PGC-1α expression, up regulates apelin gene expression and also apelin secretion in human and mice adipocytes. Moreover, during cold exposure in mice, a physiological situation known to induce both cAMP and PGC-1α, apelin expression in adipocytes and plasma levels were increased. This is the first demonstration that PGC-1α is involved in the regulation of an adipokine gene expression and release.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Peptides - Volume 150, Issues 1â3, 9 October 2008, Pages 33-37
Journal: Regulatory Peptides - Volume 150, Issues 1â3, 9 October 2008, Pages 33-37
نویسندگان
Anne Mazzucotelli, Carole Ribet, Isabelle Castan-Laurell, Danièle Daviaud, Charlotte Guigné, Dominique Langin, Philippe Valet,