کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2023180 1542437 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Brain Natriuretic Peptide (BNP) regulates the production of inflammatory mediators in human THP-1 macrophages
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Brain Natriuretic Peptide (BNP) regulates the production of inflammatory mediators in human THP-1 macrophages
چکیده انگلیسی

Brain Natriuretic Peptide (BNP), besides retaining vasodilatory, diuretic and natriuretic properties, is a vasoactive hormone that it is also involved in several cardiac diseases as well as severe sepsis and septic shock. All these conditions are characterized by an ongoing inflammatory response consisting in a complex interaction of pleiotropic mediators derived from plasma or cells, including monocytes and macrophages. However, the relationship between this hormone and inflammation remains to be elucidated. Therefore, the aim of the present study was to evaluate a possible BNP immunomodulatory activity on macrophages. Our results demonstrate that BNP regulates the production of major inflammatory molecules, such as reactive oxygen- and nitrogen species (ROS and RNS), leukotriene B4 (LTB4), prostaglandin E2 (PGE2); modulates the cytokines (TNF-α, IL-12 and IL-10) profile, and affects cell motility. These results furnish novel and brand-new proofs on BNP ability of modulating the production of inflammatory mediators in macrophages whose role has broad implications in inflammatory states where increased BNP levels have been reported.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Peptides - Volume 148, Issues 1–3, 5 June 2008, Pages 26–32
نویسندگان
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