کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2023237 | 1542439 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hypothalamic gene expression following ghrelin therapy to gastrectomized rodents
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
We investigated whether ghrelin depletion (by gastrectomy surgery) and/or treatment/replacement with the gastric hormone ghrelin alters the expression of key hypothalamic genes involved in energy balance, in a manner consistent with ghrelin's pro-obesity effects. At 2Â weeks after surgery mice were treated with ghrelin (12Â nmol/mouse/day, sc) or vehicle for 8Â weeks. Gastrectomy had little effect on the expression of these genes, with the exception of NPY mRNA in the arcuate nucleus that was increased. Ghrelin treatment (to gastrectomized and sham mice) increased the mRNA expression of orexigenic peptides NPY and AgRP while decreasing mRNA expression of the anorexigenic peptide POMC. Two weeks gavage treatment with the ghrelin mimetic, MK-0677, to rats increased NPY and POMC mRNA in the arcuate nucleus and MCH mRNA in the lateral hypothalamus. Thus, while predicted pro-obesity ghrelin signalling pathways were activated by ghrelin and ghrelin mimetics, these were largely unaffected by gastrectomy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Peptides - Volume 146, Issues 1â3, 7 February 2008, Pages 176-182
Journal: Regulatory Peptides - Volume 146, Issues 1â3, 7 February 2008, Pages 176-182
نویسندگان
Emil Egecioglu, Björn Stenström, Scarlett B. Pinnock, Loraine Y.C. Tung, Charlotta Dornonville de la Cour, Andreas Lindqvist, Rolf HÃ¥kanson, Unni Syversen, Duan Chen, Suzanne L. Dickson,