Possible role of adrenomedullin in the regulation of Fontan circulation: Mature form of plasma adrenomedullin is extracted in the lung in patients with Fontan procedure

Conclusions: Results suggest that in Fontan circulation plasma AM-m is increased in parallel with those of AM-T and AM-Gly and that AM-m is extracted in the lung. Extracted AM-m may be involved in the regulation of pulmonary arterial tonus, although further studies are necessary to elucidate the exact role of AM in Fontan circulation.