کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2023955 1069831 2006 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inflammation-associated immune suppression in cancer: The roles played by cytokines, chemokines and additional mediators
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Inflammation-associated immune suppression in cancer: The roles played by cytokines, chemokines and additional mediators
چکیده انگلیسی

Chronic inflammation and presence of inflammatory cells, primarily macrophages, at tumor sites are highly associated with specific malignancies. In these cases, the inflammatory milieu is overloaded with mediators that suppress immune activities at many levels: recognition of tumor-associated antigens, activation, the actual cytolysis of tumor cells and more. Local suppression of leukocyte functions at the inflammatory tumor site further contributes to profound immunosuppression of potential anti-tumor immune functions. The present review discusses the inflammatory setup in tumors and the factors inducing the presence of detrimental inflammatory macrophages at tumor sites. Moreover, the different mediators that contribute to inflammation-associated immune suppression, including primarily cytokines and chemokines but also prostaglandins and oxidants, are described. Bearing in mind the notion that under specific conditions the inflammatory mediators clearly contribute to malignancy, while in others they may exert surveillance missions against tumor cells, the potential therapeutic value of the inflammatory components is discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cancer Biology - Volume 16, Issue 1, February 2006, Pages 38–52
نویسندگان
,