کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2024032 | 1069841 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
KI, WU and Merkel cell polyomaviruses: A new era for human polyomavirus research
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The recent discoveries of KI, WU, and Merkel cell polyomaviruses (PyVs) have rekindled interest in the Polyomaviridae and their relation to human disease. Although it may be too early to draw firm conclusions, it seems apparent that these new viruses follow precedents established by other Py viruses: a benign initial infection at an early age, widespread prevalence in the population, and pathologic consequences only in the elderly and/or immunosuppressed. The discovery of Merkel cell PyV (MCPyV) integration into the malignant cell genome immediately implicates this agent in an oncogenic process predicted by previous research with SV40 and murine PyV (MPyV). Their discovery is another reminder that we certainly have not seen the end of novel human polyomavirus identification, but rather the beginning of a new era.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cancer Biology - Volume 19, Issue 4, August 2009, Pages 270-275
Journal: Seminars in Cancer Biology - Volume 19, Issue 4, August 2009, Pages 270-275
نویسندگان
Tina Dalianis, Torbjörn Ramqvist, Kalle Andreasson, Jaime M. Kean, Robert L. Garcea,