کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2024097 1069854 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Activation-induced non-responsiveness (anergy) limits CD8 T cell responses to tumors
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Activation-induced non-responsiveness (anergy) limits CD8 T cell responses to tumors
چکیده انگلیسی
Naïve CD8 T cells respond to signals provided by Ag, costimulation and cytokines by proliferating and differentiating to develop effector functions. Following initial clonal expansion, however, the cells develop activation-induced non-responsiveness (AINR), a form of anergy characterized by an inability to produce IL-2. Cells in the AINR state can carry out effector functions (cytolysis, IFN-γ production) but cannot continue to proliferate and expand in the face of persisting Ag. AINR limits the ability of activated CTL to control tumor growth but can be reversed by IL-2, provided either therapeutically or by activated CD4 T helper cells, to allow continued expansion.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cancer Biology - Volume 17, Issue 4, August 2007, Pages 299-308
نویسندگان
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