کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2024210 1069888 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
HLA-G in the skin—Friend or foe?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
HLA-G in the skin—Friend or foe?
چکیده انگلیسی

Skin is the largest organ of the human body that harbors a robust and versatile immune surveillance system. Whereas impaired immune function of the skin enables tumor growth, excessive immune activation results in different inflammatory diseases of the skin. HLA-G is a non-classical MHC class I molecule that was initially described to provide immunotolerogenic signals. In this context, HLA-G was mainly investigated as a mechanism that tumor cells employ to evade and inhibit host immune response. Expression of HLA-G in several inflammatory conditions in the skin implicated that the (dys)function of this molecule may also underlie excessive immune stimulation observed in these disorders. This review focuses on the functionality of HLA-G in the skin and summarizes available data obtained from studies performed in skin cancer and inflammatory dermatoses.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cancer Biology - Volume 17, Issue 6, December 2007, Pages 480–484
نویسندگان
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