کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2024228 1069896 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillance
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillance
چکیده انگلیسی

Natural killer (NK) cells have important functions in the innate immunity to tumors. Recognition of tumor cells by NK cells is mediated by the interaction of activating and inhibitory NK cell receptors with ligands expressed on the tumor target. In addition, NK cell–target cell interactions require the engagement of adhesion molecules that stabilize the cell–cell conjugate. Recently, several novel NK cell receptors have been reported to regulate NK cell adhesion and activation through interaction with ligands of the nectin and nectin-like (Necl) family of adhesion molecules. We here review current knowledge on these receptors, CD226, CD96 and CRTAM, and their role in tumor immunosurveillance.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cancer Biology - Volume 16, Issue 5, October 2006, Pages 359–366
نویسندگان
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