Polyoxygenated steroids from the gorgonian Menella woodin with capabilities to modulate ROS levels in macrophages at response to LPS

• The polyoxygenated sterols of the Vietnamese Menella woodin were investigated.
• Four new polyoxygenated steroids were isolated and structurally elucidated.
• Three isolated steroids have shown a reduction of ROS levels in macrophages.

Four new polyoxygenated sterol derivatives (1–4) along with the compounds (5–7) previously known from other biological sources were isolated from the gorgonian Menella woodin, collected from the Vietnamese waters. Structures of 1–4 were elucidated by the detailed NMR spectroscopic and mass-spectrometric analyses as well as comparison with those reported in literature data. Compounds 1, 4, and 6 decrease the production of reactive oxygen species (ROS) by the murine macrophages of RAW 264.7 line at induction by endotoxic lipopolysaccharide (LPS) from Escherichia coli.

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