کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2027893 1542719 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Adverse health effects of testosterone deficiency (TD) in men
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Adverse health effects of testosterone deficiency (TD) in men
چکیده انگلیسی


• Testosterone deficiency (TD) promotes inflammation and insulin resistance.
• TD is associated with unfavorable lipid profiles and endothelial dysfunction.
• TD is also associated with vascular stiffness, hypertension and atherosclerosis.
• TD is associated with increased cardiovascular risk and increased risk of mortality.
• TD is associated with increased sexual dysfunction and reduced quality of life.

Testosterone and its metabolite, 5α-dihydrotestosterone are critical metabolic and vascular hormones, which regulate a host of biochemical pathways including carbohydrate, lipid and protein metabolism and modulate vascular function. Testosterone deficiency (TD) is a well-recognized medical condition with important health implications. TD is associated with a number of co-morbidities including increased body weight, adiposity and increased waist circumference, insulin resistance (IR) and type 2 diabetes mellitus (T2DM), hypertension, inflammation, atherosclerosis and cardiovascular disease, erectile dysfunction (ED) and increased incidence of mortality. In this review, we summarize the data in the literature on the prevalence of TD and its association with the various co-morbidities and suggest that T therapy is necessary to improve health outcomes in men with TD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Steroids - Volume 88, October 2014, Pages 106–116
نویسندگان
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