Preparation, preliminary screening of new types of steroid conjugates and their activities on steroid receptors

There were synthesized new types of ribbon type steroidal dimers derived from three types of steroidal skeletons (cholic acid, etienic acid, estrone) using CuI catalyzed 1, 3-dipolar cycloaddition reaction. Steroid parts of the molecular “ribbons” are linked by heterocyclic moiety, namely by 2,6-bis((1H-1,2,3-triazol-1-yl)-methyl)pyridine. Compounds synthesized possess different cytotoxic and hormone receptor modulating activities.

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► New types of ribbon type steroidal dimers synthesized using 1,3-dipolar cycloaddition reaction.
► Reaction linked by heterocyclic moiety, namely by 2,6-bis((1H-1,2,3-triazol-1-yl)methyl)pyridine.
► Compounds synthesized possess different cytotoxic and hormone receptor modulating activities.