کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2027975 1070386 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reaction of pregnenolone with cyanoacetylhydrazine: Novel synthesis of hydrazide–hydrazone, pyrazole, pyridine, thiazole, thiophene derivatives and their cytotoxicity evaluations
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Reaction of pregnenolone with cyanoacetylhydrazine: Novel synthesis of hydrazide–hydrazone, pyrazole, pyridine, thiazole, thiophene derivatives and their cytotoxicity evaluations
چکیده انگلیسی

Pregnenolone (1) was used as a template to develop new anticancer compounds. Ring D modification of 1 through its reaction with cyanoacetylhydrazine (2) gave the hydrazide–hydrazone derivative 3. The latter compound underwent heterocyclization reactions to give the pyrazole, pyridine, thiazole and thiophene derivatives of pregnenolone. The cytotoxicity of the newly synthesized heterocyclic steroids against three human tumor cell lines namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) were studied. Some of tested compounds were found to exhibit much higher inhibitory effects towards the three tumor cell lines than the reference drug, doxorubicin.

Figure optionsDownload as PowerPoint slideHighlights
► Synthesis of pyrazole, thiophene and thiazole derivatives of pregnenolone.
► Structures of the newly synthesized products were confirmed.
► Anti-tumor evaluations of the newly synthesized products against cancer cell lines.
► Some of the new pregnenolone derivatives showed high cytotoxicity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Steroids - Volume 77, Issue 14, December 2012, Pages 1551–1559
نویسندگان
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