کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2029665 | 1070945 | 2015 | 8 صفحه PDF | دانلود رایگان |
• Mimivirus fibers play an important role during infection
• First structure of a major component of the Mimivirus fiber
• Member of the GMC oxidoreductase family
• R135 is probably involved in the infection of alternative hosts
SummaryMimivirus was initially identified as a bacterium because its dense, 125-nm-long fibers stained Gram-positively. These fibers probably play a role during the infection of some host cells. The normal hosts of Mimivirus are unknown, but in the laboratory Mimivirus is usually propagated in amoeba. The structure of R135, a major component of the fibrous outer layer of Mimivirus, has been determined to 2-Å resolution. The protein's structure is similar to that of members of the glucose-methanol-choline oxidoreductase family, which have an N-terminal FAD binding domain and a C-terminal substrate recognition domain. The closest homolog to R135 is an aryl-alcohol oxidase that participates in lignin biodegradation of plant cell walls. Thus R135 might participate in the degradation of their normal hosts, including some lignin-containing algae.
Graphical AbstractFigure optionsDownload high-quality image (243 K)Download as PowerPoint slide
Journal: - Volume 23, Issue 6, 2 June 2015, Pages 1058–1065