Structure of D-AKAP2:PKA RI Complex: Insights into AKAP Specificity and Selectivity

► Crystal structures of the PKA RI isoform alone and in complex with D-AKAP2 ► Structures reveal the importance of a redox-sensitive disulfide in AKAP binding ► Unexpected shift in D-AKAP2 helical register compared to RII:D-AKAP2 structure ► Differential binding mode helps decipher the code for isoform-specific AKAP docking