کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2030577 1071219 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Host factors for retroviral integration site selection
ترجمه فارسی عنوان
عوامل میزبان برای انتخاب یک سایت مجتمع مجدد رتروویروسی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


• LEDGF/p75 and BET are the targeting factors for lentiviral and gammaretroviral integration.
• Both chromatin-readers link the fate of the provirus with the epigenetic status of the chromatin.
• LEDGINs are novel antivirals that interfere with the interaction between HIV integrase and LEDGF/p75.
• Re-engineered LEDGF/p75 and BET tethers may open new avenues for safer gene therapy.

To achieve productive infection, retroviruses such as HIV stably integrate their reverse transcribed RNA genome into a host chromosome. Each retroviral family preferentially integrates near a unique subset of genomic features. HIV integrase (IN) is targeted to the body of active transcription units through interaction with lens epithelium-derived growth factor (LEDGF/p75). We describe the successful effort to develop inhibitors of the interaction between IN and LEDGF/p75, referred to as LEDGINs. Gammaretroviruses display a distinct integration pattern. Recently, BET (bromo- and extraterminal domain) proteins were identified as the LEDGF/p75 counterparts that target the integration of gammaretroviruses. The identification of the chromatin-readers LEDGF/p75 and BET as cellular cofactors that orchestrate lentiviral or gammaretroviral integration opens new avenues to developing safer viral vectors for gene therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 40, Issue 2, February 2015, Pages 108–116
نویسندگان
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