کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2030809 1071251 2013 19 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
SET for life: biochemical activities and biological functions of SET domain-containing proteins
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
SET for life: biochemical activities and biological functions of SET domain-containing proteins
چکیده انگلیسی


• An overview on the substrates of SET domain-containing proteins is provided.
• Protein complexes of SET domain-containing proteins are described.
• Biological functions of different classes of SET domain-containing proteins are discussed.SET domain-containing proteins belong to a group of enzymes named after a common domain that utilizes the cofactor S-adenosyl-l-methionine (SAM) to achieve methylation of its substrates. Many SET domain-containing proteins have been shown to display catalytic activity towards particular lysine residues on histones, but emerging evidence also indicates that various non-histone proteins are specifically targeted by this clade of enzymes. Here, we summarize the most recent findings on the biological functions of the major families of SET domain-containing proteins catalyzing the methylation of histones 3 on lysines 4, 9, 27, and 36 (H3K4, H3K9, H3K27, and H3K36) and histone 4 on lysine 20 (H4K20), as well as enzymes that have been reported to modify non-histone substrates.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 38, Issue 12, December 2013, Pages 621–639
نویسندگان
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