کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2030836 1071254 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Selenium and selenocysteine: roles in cancer, health, and development
ترجمه فارسی عنوان
سلنیوم و سلنوسیستئین: نقش در سرطان، سلامت و توسعه
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


• Selenocysteine is the 21st amino acid in the genetic code.
• Selenoproteins are largely responsible for the many health benefits of selenium.
• Some selenoproteins exhibit a split personality in preventing and promoting cancer.

The many biological and biomedical effects of selenium are relatively unknown outside the selenium field. This fascinating element, initially described as a toxin, was subsequently shown to be essential for health and development. By the mid-1990s selenium emerged as one of the most promising cancer chemopreventive agents, but subsequent human clinical trials yielded contradictory results. However, basic research on selenium continued to move at a rapid pace, elucidating its many roles in health, development, and in cancer prevention and promotion. Dietary selenium acts principally through selenoproteins, most of which are oxidoreductases involved in diverse cellular functions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 39, Issue 3, March 2014, Pages 112–120
نویسندگان
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