SOX15 Governs Transcription in Human Stratified Epithelia and a Subset of Esophageal Adenocarcinomas

These data identify a novel transcriptional regulator of stratified epithelial cells and a subtype of EAC with bi-lineage gene expression. Broad activation of squamous-cell genes may shed light on whether EACs arise in the native stratified epithelium or in ectopic columnar cells.