کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2043801 | 1073378 | 2008 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Calcium-Activated Myosin V Closes the Drosophila Pupil Calcium-Activated Myosin V Closes the Drosophila Pupil](/preview/png/2043801.png)
SummaryApproximately 40 years ago, an elegant automatic-gain control was revealed in compound eye photoreceptors: In bright light, an assembly of small pigment granules migrates to the cytoplasmic face of the photosensitive membrane organelle, the rhabdomere, where they attenuate waveguide propagation along the rhabdomere 1, 2 and 3. This migration results in a “longitudinal pupil” that reduces rhodopsin exposure by a factor of 0.8 log units 3 and 4. Light-induced elevation of cytosolic free Ca2+ triggers the migration of pigment granules 5, 6 and 7, and pigment granules fail to migrate in a mutant deficient in photoactivated TRP calcium channels 8 and 9. However, the mechanism that moves photoreceptor pigment granules remains elusive. Are the granules actively pulled toward the rhabdomere upon light, or are they instead actively pulled into the cytoplasm in the absence of light? Here we show that Ca2+-activated Myosin V (MyoV) pulls pigment granules to the rhabdomere. Thus, one of MyoV's several functions 10 and 11 is also as a sensory-adaptation motor. In vitro, Ca2+ both activates and inhibits MyoV motility 12, 13, 14, 15 and 16; in vivo, its role is undetermined. This first demonstration of an in vivo role for Ca2+ in MyoV activity shows that in Drosophila photoreceptors, Ca2+ stimulates MyoV motility.
Journal: - Volume 18, Issue 13, 8 July 2008, Pages 951–955