کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2048514 | 1074082 | 2012 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: MiR-219-5p inhibits hepatocellular carcinoma cell proliferation by targeting glypican-3 MiR-219-5p inhibits hepatocellular carcinoma cell proliferation by targeting glypican-3](/preview/png/2048514.png)
MicroRNAs (miRNAs) have been linked to the molecular pathogenesis of many cancers. In this study, we found that miR-219-5p was significantly downregulated in 83 HCC tissues and three HCC cell lines, compared to their non-tumor counterparts. MiR-219-5p expression correlated with tumor size, histological differentiation, and overall survival time in HCC patients. We also found that miR-219-5p could inhibit cell proliferation in vitro and arrest cell cycle at the G1 to S transition. Further studies identified that miR-219-5p reduced both the mRNA and protein levels of glypican-3 (GPC3). These findings indicate that miR-219-5p exerts tumor-suppressive effects in hepatic carcinogenesis through negative regulation of GPC3 expression.
► MiR-219-5p is significantly downregulated in HCC.
► MiR-219-5p expression is correlated with larger tumor size, and shorter overall survival time.
► MiR-219-5p exerts tumor-suppressive effects in HCC carcinogenesis.
► GPC3 is a direct downstream of miR-219-5p.
Journal: FEBS Letters - Volume 586, Issue 6, 23 March 2012, Pages 884–891