کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2048514 1074082 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
MiR-219-5p inhibits hepatocellular carcinoma cell proliferation by targeting glypican-3
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
MiR-219-5p inhibits hepatocellular carcinoma cell proliferation by targeting glypican-3
چکیده انگلیسی

MicroRNAs (miRNAs) have been linked to the molecular pathogenesis of many cancers. In this study, we found that miR-219-5p was significantly downregulated in 83 HCC tissues and three HCC cell lines, compared to their non-tumor counterparts. MiR-219-5p expression correlated with tumor size, histological differentiation, and overall survival time in HCC patients. We also found that miR-219-5p could inhibit cell proliferation in vitro and arrest cell cycle at the G1 to S transition. Further studies identified that miR-219-5p reduced both the mRNA and protein levels of glypican-3 (GPC3). These findings indicate that miR-219-5p exerts tumor-suppressive effects in hepatic carcinogenesis through negative regulation of GPC3 expression.


► MiR-219-5p is significantly downregulated in HCC.
► MiR-219-5p expression is correlated with larger tumor size, and shorter overall survival time.
► MiR-219-5p exerts tumor-suppressive effects in HCC carcinogenesis.
► GPC3 is a direct downstream of miR-219-5p.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 586, Issue 6, 23 March 2012, Pages 884–891
نویسندگان
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