کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2048617 | 1074086 | 2011 | 7 صفحه PDF | دانلود رایگان |
Argonaute are a conserved class of proteins central to the microRNA pathway. We have highlighted a novel and non-redundant function of Ago1 versus Ago2; the two core factors of the miRNA-associated RISC complex. Stable overexpression of Ago1 in neuroblastoma cells causes the cell cycle to slow down, a decrease in cellular motility and a stronger apoptotic response upon UV irradiation. These effects, together with a significant increase in p53 levels, suggest that Ago1 may act as a tumor-suppressor factor, a function also supported by GEO Profiles microarrays that inversely correlate Ago1 expression levels with cell proliferation rates.
► Ago1 overexpression has a tumor suppressor like behaviour in SH-SY5Y.
► Both Ago1 and Ago2 can affect differentiation in SH-SY5Y.
► p53 Levels are strongly up-regulated as a consequence of Ago1 overexpression.
Journal: FEBS Letters - Volume 585, Issue 19, 3 October 2011, Pages 2965–2971