کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2048784 | 1074100 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The conundrum of inhibitory signaling by ITAM-containing immunoreceptors: Potential molecular mechanisms
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The conundrum of inhibitory signaling by ITAM-containing immunoreceptors: Potential molecular mechanisms The conundrum of inhibitory signaling by ITAM-containing immunoreceptors: Potential molecular mechanisms](/preview/png/2048784.png)
چکیده انگلیسی
Immunoreceptor signals must be appropriately transduced and regulated to achieve effective immunity while controlling inflammation and autoimmunity. It is generally held that these processes are mediated by the interplay of distinct activating and inhibitory receptors via conserved activating (ITAM) and inhibitory (ITIM) signaling motifs. However, recent evidence indicates that under certain conditions incomplete phosphorylation of ITAM tyrosines leads to inhibitory signaling. This new regulatory function of ITAMs has been termed ITAMi (inhibitory ITAM). Here we discuss the potential molecular mechanisms of inhibitory signaling by ITAM-containing receptors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 24, 15 December 2010, Pages 4878–4882
Journal: FEBS Letters - Volume 584, Issue 24, 15 December 2010, Pages 4878–4882
نویسندگان
Paul M. Waterman, John C. Cambier,