Keywords: PCOS; polycystic ovary syndrome; NK; natural killer; uNK; uterine natural killer; KIRs; killer-cell immunoglobulin-like receptors; iKIR; Kir inhibitors; ITIM; tyrosine-based inhibitory motifs; aKIR; Kir activators; ITAM; tyrosine-based activation motifs;
مقالات ISI (ترجمه نشده)
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Keywords: ADA; anti-drug antibodies; AMPK; 5â² adenosine monophosphate-activated protein kinase; aHUS; atypical hemolytic uremic syndrome; AMD; age-related macular degeneration; APC; antigen presenting cells; AT; anaphylatoxin; BTK; Bruton's tyrosine kinase; C1q
Keywords: AP-1; activating protein 1; APC; antigen presenting cell; CAR; chimeric antigen receptors; Cbl-b; casitas B-lineage lymphoma; DAG; diacylglycerol; cSMAC; central supramolecular activation cluster; CTLA4; cytotoxic T lymphocyte antigen 4; dSMAC; distal sup
Keywords: Gene content haplotype; Novel immune-type receptors; Diverse immunoglobulin domain containing proteins; Polymeric immunoglobulin receptor-like proteins; Novel immunoglobulin-like transcripts; DICPs; diverse immunoglobulin domain containing proteins; Ig; i
Keywords: AIHA; autoimmune hemolytic anemia; ASH; American Society of Hematology; CLL; chronic lymphocytic leukemia; CMV; cytomegalovirus; CVID; common variable immunodeficiency; GPRD; General Practice Research Database; DIC; disseminated intravascular coagulation;
Keywords: FACS; fluorescence activated cell sorting; MHCI; MHC class I molecules; MHCII; MHC class II molecules; APC; antigen-presenting cells; DC; dendritic cells; TCR; T cell receptor; MVB; multi-vesicular body; ILV; intraluminal vesicles; MARCH; membrane-associa
Keywords: AP-1; activator protein-1; BLNK; B cell linker protein; BTK; Bruton's tyrosine kinase; CCT; choline cytidylyltransferase; CDP-choline; cytidine diphosphocholine; CEPT1; choline/ethanolamine phosphotransferase 1; Cer; ceramide; CK; choline kinase; CPT1; ch
Keywords: Abl; Abelson leukemia proto-oncogene; ADAP; adhesion and degranulation promoting adapter protein (Fyb, SLAP-130); Asc; apoptosis-associated speck-like protein containing a CARD; BCR; B-cell receptor; C3G; Crk SH3 domain-binding guanine nucleotide exchange
TREM2 overexpression attenuates neuroinflammation and protects dopaminergic neurons in experimental models of Parkinson's disease
Keywords: AD; Alzheimer's disease; CNS; central nervous system; DA; dopamine; DOPAC; dihydroxyphenylacetic acid; ESI; electrospray interface; FTD; frontotemporal dementia; HPLC-MS/MS; high-performance liquid chromatography-tandem mass spectrometry; HVA; homovanilli
Immune suppression of food allergy by maternal IgG in murine models
Keywords: Allergic diseases; Food allergy; Immunoglobulins; Oral tolerance; Ovalbumin; ITAM; Immunoreceptor tyrosine-based activation motifs; ITIM; Immunoreceptor tyrosine-based inhibitory motifs;
The natural sesquiterpene lactones arglabin, grosheimin, agracin, parthenolide, and estafiatin inhibit T cell receptor (TCR) activation
Keywords: Sesquiterpene lactones; Jurkat T cells; T cell receptor; Kinase; Phosphorylation; Calcium flux; Glutathione; DMSO; dimethyl sulfoxide; FBS; fetal bovine serum; FPR; N-formyl peptide receptor; HBSS; Hanks' balanced salt solution; IP3; inositol triphosphate
The avidity of cross-reactive virus-specific T cells for their viral and allogeneic epitopes is variable and depends on epitope expression
Keywords: Allo-HLA; allogeneic HLA; CMV; cytomegalovirus; CRA; 51chromium-release assay; EBV-LCL; Epstein-Barr Virus transformed lymphoblastoid cell line; ELISA; enzyme-linked immunosorbent assay; FACS; fluorescence-activated cell sorting; FCS; fetal calf serum; FI
Pulsatilla decoction inhibits Candida albicans proliferation and adhesion in a mouse model of vulvovaginal candidiasis via the Dectin-1 signaling pathway
Keywords: PD; Pulsatilla decoction; TCM; Traditional Chinese Medicine; VVC; Vulvovaginal candidiasis; HPLC; High performance liquid chromatography; CFU; Colony forming unit; PAS; Periodic acid schiff; H&E; Hematoxylin and eosin; SEM; Scanning electron microscopy; C
High affinity sugar ligands of C-type lectin receptor langerin
Keywords: CLR; C-type lectin receptor; DC; dendritic cell; Gal; galactose; KS; keratan sulfate; Tri; trimeric; LC; Langerhans cell; CRD; carbohydrate recognition domain; COPD; chronic obstructive pulmonary disease; langerin-S; langerin monomer; langerin-L; langerin
BCAP promotes osteoclast differentiation through regulation of the p38-dependent CREB signaling pathway
Keywords: BCAP; B-cell adaptor for PI3K; PI3K; phosphatidylinositol 3-Kinase; BMM; bone marrow-derived monocyte/macrophage lineage cell; NFATc1; nuclear factor of activated T-cells c1; TRAP; tartrate-resistant acid phosphatase; RANKL; receptor activator of nuclear
Anti-FcγRIIB mAb suppresses murine IgG-dependent anaphylaxis by Fc domain targeting of FcγRIII
Keywords: Fc receptors; anaphylaxis; mouse; signaling; IgG; IgE; EW; Chicken egg white; FcγR; Fcγ receptor; FcRγ; Fc receptor γ chain; FSC; Forward scatter; ITAM; Immunoreceptor tyrosine-based activation domain; ITIM; Immunoreceptor tyrosine-based inhibitory do
Siglecs: A journey through the evolution of sialic acid-binding immunoglobulin-type lectins
Keywords: Siglecs; Sialic acids; Vertebrate evolution; ITIM; ITAM; Lectin;
Reformation in chimeric antigen receptor based cancer immunotherapy: Redirecting natural killer cell
Keywords: NK cell; natural killer cell; IFN-γ; interferon-γ; IL; interleukin; TNF-α; tumor necrosis factor-α; CCL; C-C motif ligand; GM-CSF; granulocyte-macrophage colony-stimulating factor; ADCC; antibody dependent cell-mediated cytotoxicity; TRAIL; TNF-relate
TCR crosslinking promotes Crk adaptor protein binding to tyrosine-phosphorylated CD3ζ chain
Keywords: T cell activation; TCR/CD3 crosslinking; CD3ζ chain; Crk adaptor proteins; Tyrosine phosphorylation; Signal transduction; C3G; Crk SH3 domain-binding guanine nucleotide-releasing factor; Crk; CT10 (chicken tumor virus number 10) regulator of kinase; CrkL
New insights in the pathogenesis of immunoglobulin A vasculitis (Henoch-Schönlein purpura)
Keywords: ADCC; antibody-dependent cellular cytotoxicity; AECA; Anti-epithelial cell antibodies; ANCA; Anti-neutrophil cytoplasmic antibodies; β2GPI; β2-glycoprotein I; CDC; Complement-dependent cytotoxicity; EC; endothelial cell; FcαRI; Fc receptor for IgA; Gal
Proximal signaling responses in peripheral T cells from colorectal cancer patients are affected by high concentrations of circulating prostaglandin E2
Keywords: BD; blood donors; CEA; carcinoembryonic antigen; COX; cyclooxygenase; CRC; colorectal cancer; FCB; fluorescence cell barcoding; ITAM; immunoreceptor tyrosine based activation motif; MFI; median fluorescence intensity; ND; not determined; NSAID; non-steroi
Imaging flow cytometry and GST pulldown assays provide new insights into channel catfish leukocyte immune-type receptor-mediated phagocytic pathways
Keywords: Phagocytosis; Immunoregulatory receptors; Intracellular signaling; Actin polymerization machinery; Imaging flow cytometry; Innate immunity; Channel catfish; Leukocyte immune-type receptors; IpLITR; channel catfish leukocyte immune-type receptor; CYT; cyto
Chimeric antigen receptor T-cells for B-cell malignancies
Keywords: ALL; acute lymphoblastic leukemia; B-ALL; B-cell acute lymphoblastic leukemia; CAR-T; chimeric antigen receptor T-cell; CAR; chimeric antigen receptor; CD; cluster of differentiation; CHOP; Children's Hospital of Philadelphia; CLL; chronic lymphocytic leu
Crk adaptor proteins regulate CD3ζ chain phosphorylation and TCR/CD3 down-modulation in activated T cells
Keywords: Abl; Abelson tyrosine kinase; C3G; Crk SH3 domain-binding guanine nucleotide-releasing factor; Cbl; Casitas B-lineage lymphoma; CD3ζY1-6F; CD3ζ mutant in which all 6 tyrosines were replaced by phenylalanine; Crk; CT10 (chicken tumor virus number 10) reg
Suppression of IgE-mediated mast cell activation and mouse anaphylaxis via inhibition of Syk activation by 8-formyl-7-hydroxy-4-methylcoumarin, 4μ8C
Keywords: 8-Formyl-7-hydroxy-4-methylcoumarin; 4μ8C; Mast cells; Allergy; Anaphylaxis; Lyn; Fyn; BMMC; Bone marrow-derived mast cell; RBL; Rat basophilic leukemia; PCA; Passive cutaneous anaphylaxis; ITAM; Immunoreceptor tyrosine-based activation motif; DNP-BSA; D
E3 ubiquitin ligase CHIP interacts with C-type lectin-like receptor CLEC-2 and promotes its ubiquitin-proteasome degradation
Keywords: CLEC-2; C-type lectin-like receptor 2; CHIP; C terminus of Hsc70-interacting protein; PMA; phorbol myristate acetate; CHX; cycloheximide; HEK293T; human emborynic kidney 293T; MS; mass spectrometry; FACS; fluorescence-activated cell sorting; ITAM; immunor
A differential gene expression study: Ptpn6 (SHP-1)-insufficiency leads to neutrophilic dermatosis-like disease (NDLD) in mice
Keywords: Ptpn6; tyrosine phosphatase, non-receptor type-6; Hcph; hematopoietic cell phosphatase; Shp-1; Src homology 2 domain-containing tyrosine phosphatase 1; ITIM; immunoreceptor tyrosine-based inhibitory motif; ITAM; immunoreceptor tyrosine-based activation mo
MALT1 Protease Activity Controls the Expression of Inflammatory Genes in Keratinocytes upon Zymosan Stimulation
Keywords: AMPs; antimicrobial peptides; CBM; CARMA1-BCL10-MALT1; DAG; diacylglycerol; I; ionomycin; ITAM; immunoreceptor tyrosine-based activation motif; KCs; keratinocytes; MALT1; mucosa-associated lymphoid tissue lymphoma translocation gene 1; PKC; protein kinas
Immunoreceptors on neutrophils
Keywords: ADCC; antibody-dependent cellular cytotoxicity; ANCAs; anti-neutrophil autoantibodies; Btk; Bruton's tyrosine kinase; DAG; diacyl-glycerol; DAP12; DNAX activation protein of 12Â kDa; ERK; extracellular signal-regulated kinase; fMLP; N-Formylmethionine-leu
Fifty years later: Emerging functions of IgE antibodies in host defense, immune regulation, and allergic diseases
Keywords: IgE; mast cells; anaphylaxis; ADAM; A disintegrin and metalloproteinase; AID; Activation-induced cytidine deaminase; APC; Antigen-presenting cell; BAFF; BÂ cell-activating factor of the TNF family; CSR; Class-switch recombination; DC; Dendritic cell; DS
The Paracaspase MALT1
Keywords: NF-κB signaling; Protease; Caspase; Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1); ABC; activated B cell-like; ABC-DLBCL; activated B cell-like diffuse large B cell lymphoma; Ac; acetyl; ALL; acute lymphomblastic leukemia; AM
Spleen Tyrosine Kinase Mediates EGFR Signaling to Regulate Keratinocyte Terminal Differentiation
Keywords: ITAM; immunoreceptor tyrosine-based activation motif; NHEK; normal human epidermal keratinocytes; PMA; phorbol 12-myristate 13-acetate; siRNA; small interfering RNA; Syk; spleen tyrosine kinase; TGase; transglutaminase;
Microenvironment interactions and B-cell receptor signaling in Chronic Lymphocytic Leukemia: Implications for disease pathogenesis and treatment
Keywords: APRIL; a proliferation-inducing ligand; ATM; ataxia telangiectasia mutated; BAFF; B-cell activating factor; BAFFR; BAFF receptor; BAG6; BCL2-associated athanogene 6; BCMA; B-cell maturation antigen; BCL2; B-cell lymphoma 2; BCR; B cell receptor; bFGF; bas
C-Type Lectin-Like Receptor 2 Suppresses AKT Signaling and Invasive Activities of Gastric Cancer Cells by Blocking Expression of Phosphoinositide 3-Kinase Subunits
Keywords: Spleen Tyrosine Kinase; DNA Methylation; Tumor Suppressor; Inflammatory Homeostasis; CES; composite expression score; CLEC2; C-type lectin-like receptor 2; EMT; epithelial to mesenchymal transition; GSK3; glycogen synthase kinase 3; IHC; immunohistochemis
A signaling-enhanced chimeric receptor to activate the ICOS pathway in T cells
Keywords: ADA; anti-drug antibody; CD3; cluster of differentiation 3; B7RP1; B7 related protein 1; ICOS; inducible costimulator; TCR; T cell receptor; ICOS-CD3; chimeric receptor consisting of full-length ICOS and the cytoplasmic region of CD3 zeta; ITAM; immune
Original Full Length ArticleSialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) mediates periarticular bone loss, but not joint destruction, in murine antigen-induced arthritis
Keywords: AIA; antigen-induced arthritis; DAP12; DNAX-activating protein 12 kDa; FcRγ; Fc receptor common γ; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; ITAM; immunoreceptor tyrosine-based activation motif; mBSA; methylated bovine serum albumin; micro-CT; m
Signalling versatility following self and non-self sensing by myeloid C-type lectin receptors
Keywords: Innate immunity; C-type lectin receptors; Myeloid cells; BDCA; blood DC antigen; CEACAM; carcinoembryonic antigen-related cell adhesion molecule; CLR; C-type lectin receptor; CTL; cytotoxic T lymphocyte; CTLD; C-type lectin domain; DAMP; damage-associated
Retention of duplicated ITAM-containing transmembrane signaling subunits in the tetraploid amphibian species Xenopus laevis
Keywords: Xenopus; Genome mining; Activating receptor complexes; TCR; Tetraploidization; Protein dosage effect; Immunogenetics; TSS; Transmembrane Signaling Subunits; ITAM; Immunoreceptor Tyrosine-based Activation Motif; WGD; whole genome duplication; CDS; Coding S
STAM2, a member of the endosome-associated complex ESCRT-0 is highly expressed in neurons
Keywords: STAM; signal transducing adaptor molecule; VHS domain; Vps-27/Hrs/Stam domain; UIM; ubiquitin-interacting motif; SH3; Src homology 3; CC; coiled coil; SSM; STAM-specific motif; ITAM; immunoreceptor tyrosine-based activation motif; HRS; hepatocyte growth f
C. elegans positive olfactory associative memory is a molecularly conserved behavioral paradigm
Keywords: STAM; short-term associative memory; ITAM; intermediate-term associative memory; Short-term memory; Intermediate-term memory; C. elegans; cAMP; Adaptation;
A novel FcγRIIa Q27W gene variant is associated with common variable immune deficiency through defective FcγRIIa downstream signaling
Keywords: FcγR; Fc gamma receptor; CVID; common variable immunodeficiency; ITAM; immunoreceptor tyrosine-based activation motif; BCR; B cell receptor; DC; dendritic cells; MAPK; mitogen-activated protein kinase; PBMC; peripheral blood mononuclear cells; ADCC; anti
Chicken NK cell receptors
Keywords: CHIR; chicken Ig-like receptor; IEL; intestinal intraepithelial lymphocytes; ITAM; immunoreceptor tyrosine-based activation motif; ITIM; immunoreceptor tyrosine-based inhibitory motif; ITSM; immunoreceptor tyrosine-based switch motif; KIR; killer cell imm
Chicken immunoregulatory Ig-like receptor families: An overview and expression details on ggTREM-A1
Keywords: CD200R; CD200 receptor; CD300L; CD300 like antigen; CHIR; chicken Ig-like receptor; Ct; cycle threshold; DAP; DNAX activating protein; FcR; Fc receptor; GFAP; glial fibrillary acidic protein; ITAM; immunoreceptor tyrosine-based activating motif; ITIM; imm
Quantitative profiling of tyrosine phosphorylation revealed changes in the activity of the T cell receptor signaling pathway upon cisplatin-induced apoptosis
Keywords: 7-AAD; 7-amino-actinomycin D; Atf2; activating transcription factor 2; Csk; C-terminal Src kinase; Erk; extracellular-signal-regulated kinase; FCB; fluorescent cell barcoding; FSC; forward scatter; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; IL-2; in
Regulation of ITAM adaptor molecules and their receptors by inhibition of calcineurin-NFAT signalling during late stage osteoclast differentiation
Keywords: Osteoclast; ITAM; Calcineurin; NFATc1; FK506; VIVIT; β3 Integrin; Annexin VIII
Peptide LSARLAF induces integrin β3 dependent outside-in signaling in platelets
Keywords: FcRγ-chain; Fc receptor γ-chain; SLP-76; SH2 domain-containing leukocyte protein of 76 KDa; PLCγ2; phospholipase C γ 2; LAT; linker for activation of T cells; TxA2; thromboxane A2; Syk; spleen tyrosine kinase; RGDS; Arg-Gly-Asp-Ser; ITAM; immunorecep
Clinical ScienceAbnormal expression and function of Dectin-1 receptor in type 2 diabetes mellitus patients with poor glycemic control (HbA1c > 8%)
Keywords: T2D; type 2 diabetes mellitus; ROS; reactive oxygen species; ITAM; immunoreceptor tyrosine-based activation motif; TLR; toll-like receptors; APCs; antigen presenting cells; PBMC; peripheral blood mononuclear cells; ADA; American Diabetes Association; FPG;
Development of unique antibodies directed against each of the six different phosphotyrosine residues within the T cell receptor CD3ζ chain
Keywords: ITAM; immunoreceptor tyrosine-based activation motif; TCR; T cell antigen receptor; CD3ζ; the zeta chain of the TCR/CD3 complex; pTyr-CD3ζ; tyrosine phosphorylated CD3ζ; IB; immunoblot; IP; immunoprecipitation; CD3ζ chain; Tyrosine phosphorylation; Ph
Interferon gamma induces actin polymerization, Rac1 activation and down regulates phagocytosis in human monocytic cells
Keywords: IgG receptors; Macrophages; F-actin; Cytoskeleton; Phagocytosis; PI3K; DBA; 3,3â²-diaminobenzidine; FBS; fetal bovine serum; FcγR; receptor for the Fc portion of IgG; GMF; geometric mean of fluorescence intensity; HRP; horseradish peroxidase; IgG-SRBC;
Channel catfish leukocyte immune-type receptor mediated inhibition of cellular cytotoxicity is facilitated by SHP-1-dependent and -independent mechanisms
Keywords: IpLITRs; Ictalurus punctatus leukocyte immune-type receptors; SH2; Src homology 2; SHP; Src homology 2 domain-containing cytoplasmic phosphatase; Csk; C-terminal Src kinase; ITAM; immune receptor tyrosine-based activation motif; SFK; Src-family protein ty