Keywords: LTA; lipoteichoic acid; BMDCs; bone marrow-derived dendritic cells; LPS; lipopolysaccharide; LAP; LAG-3-associated protein; TOLLIP; toll interacting protein; IDO; indoleamine 2,3-dioxygenase; PepG; peptidoglycan; BLP; bacterial lipoproteins; ET; endotoxin
مقالات ISI (ترجمه نشده)
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Keywords: Missense mutations; Protein tyrosine phosphatases; SHP-1; FAP-1;
Keywords: BSA; bovine serum albumin; CK; creatine kinase; DMSO; dimethylsulfoxide; DTNB; 5,5â²-dithio-(2-nitrobenzoic acid); DTT; dithiothreitol; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; HBSS; Hank's buffered salt solution without calcium and magnesium; HM
Keywords: Macrophage activation; Lipid phosphatase; SHIP; PTEN; Protein tyrosine phosphatase; Shp2; PTPN22; PTP1B; SHP-1; Protein phosphatase; MKP-1
Keywords: RA; rheumatoid arthritis; DCs; dendritic cells; TolDCs; tolerogenic dendritic cells; NSAIDs; non-steroidal anti-inflammatory drugs; GC; glucocorticoids; DMARDs; disease-modifying anti-rheumatic drugs; TLRs; toll-like receptors; CLRs; cell surface C-type l
Keywords: Protein tyrosine phosphatase; PTP1B; CD45; CDC25; SHP-1; SHP-2; MPTP; LAR; VHR; Natural products;
Keywords: AP-1; adaptor protein 1; ASL; airway surface liquid; CCO; cytochrome c oxidase; CF; cystic fibrosis; COX-2; cyclooxygenase 2; Csk; c-src kinase; DMEM; Dulbeccos' minimal essential medium; DMT1; divalent metal ion transporter 1; DUOX; dual oxidase; EGFR;
Keywords: Abl; Abelson leukemia proto-oncogene; ADAP; adhesion and degranulation promoting adapter protein (Fyb, SLAP-130); Asc; apoptosis-associated speck-like protein containing a CARD; BCR; B-cell receptor; C3G; Crk SH3 domain-binding guanine nucleotide exchange
Keywords: ATF-4; activating transcription factor-4; ARNT; aryl hydrocarbon receptor nuclear translocator; bHLH; basic helix-loop-helix; BBB; Basso, Beattie, and Bresnahan; cFLIP; cellular FLICE-inhibitory protein; cyt C; cytochrome C; Cygb; cytoglobin; CYP2B6; cyto
A change in structural integrity of c-Kit mutant D816V causes constitutive signaling
Keywords: JAK; Janus kinase; JM region; juxtamembrane region; JNK; c-Jun N-terminal kinase; MAPK; mitogen-activated protein kinase; MD; molecular dynamics; MIHC; Myb-immortalized haemopoietic cells; WT; wild-type c-Kit; WTp; wild-type phosphorylated c-Kit; MT_D816V
DNA methyltransferase 1 mediated aberrant methylation and silencing of SHP-1 gene in chronic myelogenous leukemia cells
Keywords: CML; chronic myelogenous leukemia; DNMT; DNA methyltransferase; PCR; polymerase chain reaction; BSP; bisulfite sequencing PCR; MSP; methylation-specific PCR; SHP-1; Methylation; Gene silencing; DNMT1;
Protein tyrosine phosphatase SHP-1 modulates osteoblast differentiation through direct association with and dephosphorylation of GSK3β
Keywords: SHP-1; Osteoblast; GSK3β;
Attenuated in vitro effects of IFN-α, IL-2 and IL-12 on functional and receptor characteristics of peripheral blood lymphocytes in metastatic melanoma patients
Keywords: NK; natural Killer; CTL; cytotoxic T lymphocytes; MM; metastatic melanoma; NKG2D; natural killer group 2 D; NCR; natural cytotoxicity receptor; KIR; killer cell immunoglobulin-like receptor; HLA; human leukocyte antigen; MICA/B; MHC-class-I-polypeptide-re
Inhibition of Src homology 2 domain containing protein tyrosine phosphatase as the possible mechanism of metformin-assisted amelioration of obesity induced insulin resistance in high fat diet fed C57BL/6J mice
Keywords: Adipose tissue; Inflammation; Macrophages; Metformin; Obesity induced insulin resistance; SHP-1;
Protein tyrosine phosphatase 1B inhibitors as antidiabetic agents - A brief review
Keywords: CD45; cluster of differentiation 45; CDC25; cell division cycle 25; DFMP; difluoromethylene phosphonates; IDDM; insulin-dependent diabetes mellitus; IGT; impaired glucose tolerance; JAK2; Janus Kinase 2; IBA; imbricatolic acid; MA; maslinic acid; MAP; mit
A differential gene expression study: Ptpn6 (SHP-1)-insufficiency leads to neutrophilic dermatosis-like disease (NDLD) in mice
Keywords: Ptpn6; tyrosine phosphatase, non-receptor type-6; Hcph; hematopoietic cell phosphatase; Shp-1; Src homology 2 domain-containing tyrosine phosphatase 1; ITIM; immunoreceptor tyrosine-based inhibitory motif; ITAM; immunoreceptor tyrosine-based activation mo
A combination of sorafenib and SC-43 is a synergistic SHP-1 agonist duo to advance hepatocellular carcinoma therapy
Keywords: HCC; hepatocellular carcinoma; SHP-1; Src homology region 2 domain containing phosphatase 1; STAT3; signal transducer and activator of transcription 3; p-STAT3; phosphorylated STAT3; Raf; rapidly accelerated fibrosarcoma; VEGFR; vascular endothelial growt
Nanoencapsulated curcumin and praziquantel treatment reduces periductal fibrosis and attenuates bile canalicular abnormalities in Opisthorchis viverrini-infected hamsters
Keywords: OV; Opisthorchis viverrini; CCA; cholangiocarcinoma; NEC; nanoencapsulated curcumin; PZQ; praziquantel; PDF; periductal fibrosis; BC; bile canaliculi; Cur; curcumin; ALT; alanine transaminase; MMP; matrix metalloproteinases; TIMP; tissue inhibitors of MMP
A phosphoproteomic study reveals shp-1 cleavage reprograms LPS signaling via a PI-3K/NF-κB and mTORC1 related mechanism
Keywords: Shp-1; PI-3K; mTORC1; MODS; Phosphoproteome;
FcγRIIB mediates the inhibitory effect of aggregated α-synuclein on microglial phagocytosis
Keywords: Parkinson's disease; α-synuclein; Neuroinflammation; Microglia; Phagocytosis; SHP-1; FcγRIIB;
Signalling versatility following self and non-self sensing by myeloid C-type lectin receptors
Keywords: Innate immunity; C-type lectin receptors; Myeloid cells; BDCA; blood DC antigen; CEACAM; carcinoembryonic antigen-related cell adhesion molecule; CLR; C-type lectin receptor; CTL; cytotoxic T lymphocyte; CTLD; C-type lectin domain; DAMP; damage-associated
Role of siglecs and related glycan-binding proteins in immune responses and immunoregulation
Keywords: Siglec; selectin; dectin; glycan; glycan-binding proteins; sialic acid; treatment; glycobiology; DC-SIGN; Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin; GBP; Glycan-binding protein; ITIM; Immunoreceptor tyrosine-based
Acetyl-11-keto-β-boswellic acid reduces retinal angiogenesis in a mouse model of oxygen-induced retinopathy
Keywords: SHP-1; STAT3; VEGF; Cytochrome c; CD31-Immunohistochemistry; Electroretinogram; HRMECs; AKBA; acetyl-11-keto-β-boswellic acid; DMEM; Dulbecco's modified eagle's medium; DMSO; dimethyl sulfoxide; EBM-2; Endothelial Basal Medium-2; ELISA; enzyme-linked imm
Evaluation of Brugia malayi sheath protein (Shp-1) as a diagnostic antigen for human lymphatic filariasis
Keywords: Lymphatic filariasis; Shp-1; Sheath protein; Monoclonal antibodies; Wuchereria bancrofti; Brugia malayi; ELISA
Prostate anatomy in motheaten viable (mev) mice with mutations in the protein tyrosine phosphatase SHP-1
Keywords: Prostate; Anatomy; Differentiation; SHP-1; Motheaten viable mousePróstata; Anatomía; Diferenciación; SHP-1; Ratón motheaten viable
Anatomía de la próstata en ratones motheaten viable (mev) con mutaciones en el gen de la proteína tirosina fosfatasa SHP-1
Keywords: Próstata; Anatomía; Diferenciación; SHP-1; Ratón motheaten viableProstate; Anatomy; Differentiation; SHP-1; Motheaten viable mouse
A sorafenib derivative and novel SHP-1 agonist, SC-59, acts synergistically with radiotherapy in hepatocellular carcinoma cells through inhibition of STAT3
Keywords: SC-59; Radiation; HCC; SHP-1; Apoptosis
Research ArticleNintedanib (BIBF-1120) inhibits hepatocellular carcinoma growth independent of angiokinase activity
Keywords: HCC; hepatocellular carcinoma; Ab; antibody; IP; immunoprecipitation; p-STAT3; phosphorylated STAT3; PTPs; protein tyrosine phosphatases; SH2; Src homology region 2; SHP-1; SH2 domain-containing phosphatase 1; STAT3; signal transducer and activator of tra
The SHP-1 expression is associated with cytokines and psychopathological status in unmedicated first episode Schizophrenia patients
Keywords: PBMCs; SHP-1; Methylation; Cytokines; PANSS; Schizophrenia;
Modulation in the expression of SHP-1, SHP-2 and PTP1B due to the inhibition of MAPKs, cAMP and neutrophils early on in the development of cerulein-induced acute pancreatitis in rats
Keywords: Experimental acute pancreatitis; SHP-1; SHP-2; PTP1B; MAPK inhibition; Infiltration inhibition;
The tyrosine phosphatase SHP-1 inhibits proliferation of activated hepatic stellate cells by impairing PDGF receptor signaling
Keywords: Hepatic stellate cell; Liver fibrosis; Tyrosine phosphorylation; Protein tyrosine phosphatase; SHP-1; PDGF receptor;
Bergamottin, a natural furanocoumarin obtained from grapefruit juice induces chemosensitization and apoptosis through the inhibition of STAT3 signaling pathway in tumor cells
Keywords: Bergamottin; STAT3; SHP-1; Multiple myeloma; Apoptosis;
Taenia crassiceps infection and its excreted/secreted products inhibit STAT1 activation in response to IFN-γ
Keywords: IFN-γ; Helminths; Alternatively activated macrophages; STAT1; SOCS3; SHP-1; Immunomodulation; Excreted/secreted molecules;
Angiotensin AT2 receptor activates the cyclic-AMP signaling pathway in eel
Keywords: ATIP; AT2 receptor interacting protein; CRE; cAMP-responsive element; DIG; digoxigenin; GC; guanylyl cyclase; GPCR; G-protein coupled receptor; HEK293; human embryonic kidney cell line 293; KT5823; 2,3,9,10,11,12-hexahydro-10R-methoxy-2,9-dimethyl-1-oxo-9
Synthesis and evaluation of copper complexes of Schiff-base condensates from 5-substituted-2-hydroxybenzaldehyde and 2-substituted-benzenamine as selective inhibitors of protein tyrosine phosphatases
Keywords: Copper complexes; Protein tyrosine phosphatases; Selective inhibitor; Schiff base; CSD; Cambridge Structural Database; ESI-MS; electrospray ionization mass spectra; Hcpmp; 4-chloro-2-((phenylimino)methyl)phenol; Hnpmp; 4-bromo-2-((phenylimino)methyl)pheno
Characterization of SHP-1 protein tyrosine phosphatase transcripts, protein isoforms and phosphatase activity in epithelial cancer cells
Keywords: SHP-1; Tyrosine phosphatase; mRNA; Alternatively spliced transcripts; SHP-1 protein isoforms
Evodiamine inhibits STAT3 signaling by inducing phosphatase shatterproof 1 in hepatocellular carcinoma cells
Keywords: Evodiamine; STAT3; SHP-1; HCC; Inhibitor
Morin inhibits STAT3 tyrosine 705 phosphorylation in tumor cells through activation of protein tyrosine phosphatase SHP1
Keywords: Apoptosis; Chemosensitization; Flavonol; SHP-1; STAT3
Synthesis and biological activity of obatoclax derivatives as novel and potent SHP-1 agonists
Keywords: Obatoclax; STAT3; SHP-1; Cytotoxicity
S-nitrosylation of surfactant protein D as a modulator of pulmonary inflammation
Keywords: TLR; Toll-like receptor; TIR; Toll/IL-1 receptor domain; LPS; lipopolyssacharides; LBP; LPS-binding protein; MD-2; myeloid differentiation factor 2; MyD88; myeloid differentiation protein 88; IRAK; IL-1 receptor associated kinase; TRAF6; TNF receptor asso
Blockade of STAT3 activation by sorafenib derivatives through enhancing SHP-1 phosphatase activity
Keywords: Sorafenib; STAT3; SHP-1; HCC
A novel obatoclax derivative, SC-2001, induces apoptosis in hepatocellular carcinoma cells through SHP-1-dependent STAT3 inactivation
Keywords: HCC; hepatocellular carcinoma; STAT3; signal transducers and activators of transcription 3; SOCS; suppressor of cytokine signaling; SHP-1; Src homology region 2 domain-containing phosphatase 1; PARP; poly ADP-ribose polymerase; DMEM; Dulbecco's modified
β-Sitosterol down-regulates some pro-inflammatory signal transduction pathways by increasing the activity of tyrosine phosphatase SHP-1 in J774A.1 murine macrophages
Keywords: Macrophages; Phytosterols; β-sitosterol; NF-κB; STAT; SHP-1
Epithelial-Specific Methylation Marker: A Potential Plasma Biomarker in Advanced Non-small Cell Lung Cancer
Keywords: SHP-1; Methylation; Biomarker; Lung cancer; Epithelial-specific methylation marker
Compartmentalized CDK2 is connected with SHP-1 and β-catenin and regulates insulin internalization
Keywords: Cdk; cyclin-dependant kinase; IR; insulin receptor; PM; plasma membrane; G/E; Golgi/endosomes; PTP; protein tyrosine phosphatases; DNSHP-1; Dominant negative SHP-1; HEK; Human embryonic kidney; IIA; Insulin internalization assay; WGL; Wheat germ lectin; L
SHP-1 inhibits β-catenin function by inducing its degradation and interfering with its association with TATA-binding protein
Keywords: SHP-1; β-catenin; Intestinal epithelium; GSK3β; Tyrosine phosphorylation; Stability
Pharmacophore-based discovery of FXR agonists. Part I: Model development and experimental validation
Keywords: TUOXXRMLFZBSTB-UHFFFAOYSA-N; JTRRVYQZHXAOGI-UHFFFAOYSA-N; QMDSMBFIKFKGBD-MDZDMXLPSA-N; WPHVYHBQJIXGIJ-UHFFFAOYSA-N; FCSGTZIUJUNGAC-UHFFFAOYSA-N; GKTSXRHLYUJTSU-QHCPKHFHSA-N; SPFSVEKWCKWVLI-DEOSSOPVSA-N; SUHGVDRUULOBLM-ZXVVBBHZSA-N; CPEYWROBUIDLPI-UHFFFAOY
Pharmacophore-based discovery of FXR-agonists. Part II: Identification of bioactive triterpenes from Ganoderma lucidum
Keywords: AAJIHHYEPHRIET-XEFAKFPISA-N; DNVPQKQSNYMLRS-AWYZMFRDSA-N; AZPOACUDFJKUHJ-KRDQJDFUSA-N; LVGCWXNRZNCAJG-AMKDLFIQSA-N; SNZQBBATMLGADX-VVUVUVSISA-N; KASALCUNLBTNAA-LIPCCPSCSA-N; JVGJXXNUVVQEIG-MCKXIFHVSA-N; INIPQDKLXQHEAJ-NCQSLMINSA-N; YTVGSCZIHGRVAV-YQKBFJOX
Identification of key cytosolic kinases containing evolutionarily conserved kinase tyrosine-based inhibitory motifs (KTIMs)
Keywords: KTIM; ITIM; Kinase; SHP-1; Signalling; Innate immunity
The conundrum of inhibitory signaling by ITAM-containing immunoreceptors: Potential molecular mechanisms
Keywords: B cell; Antigen receptor; CD79; ITAM; ITIM; ITAMi; Anergy; SHIP-1; SHP-1; mIg