کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10815623 | 1058489 | 2011 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Compartmentalized CDK2 is connected with SHP-1 and β-catenin and regulates insulin internalization
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کلمات کلیدی
CDKHEKLC-MSi.p.PTPSHP-1CDK2IIaCyclin-dependant kinaseEndocytosis - آندوسیتوز یا درون بریintraperitoneal - داخل صفاقیPlasma membrane - غشای پلاسماprotein tyrosine phosphatases - پروتئین تیروزین فسفاتازhuman embryonic kidney - کلیه جنین انسانwheat germ lectin - گچ لکتینinsulin receptor - گیرنده انسولین
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The cyclin-dependant kinase Cdk2 is compartmentalized in endosomes but its role is poorly understood. Here we show that Cdk2 present in hepatic endosome fractions is strictly located in a Triton X-100-resistant environment. The endosomal Cdk2 was found to be associated with the protein tyrosine phosphatase SHP-1, a regulator of insulin clearance, and the actin anchor β-catenin, a known substrate for both Cdk2 and SHP-1. In the plasma membranes and endosome fractions, β-catenin is associated with CEACAM1, also known as regulator of insulin clearance. We show that β-catenin, not CEACAM1, is a substrate for Cdk2. Partial down-modulation of Cdk2 in HEK293 cells increased the rate of insulin internalization. These findings reveal that Cdk2 functions, at least in part, via a Cdk2/SHP-1/β-catenin/CEACAM1 axis, and show for the first time that Cdk2 has the capacity to regulate insulin internalization.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Signalling - Volume 23, Issue 5, May 2011, Pages 911-919
Journal: Cellular Signalling - Volume 23, Issue 5, May 2011, Pages 911-919
نویسندگان
Annie Fiset, Elaine Xu, Sébastien Bergeron, André Marette, Georges Pelletier, Katherine A. Siminovitch, Martin Olivier, Nicole Beauchemin, Robert L. Faure,