S-nitrosylation of surfactant protein D as a modulator of pulmonary inflammation

► Multimerization of SP-D is a critical feature of its function. ► NO is capable of modifying SP-D through S-nitrosylation. ► S-nitrosylation of SP-D causes disruption of its quaternary structure into trimers. ► The formation of SNO-SP-D trimers initiates a pro-inflammatory response. ► Disruption of SP-D multimeric state causes a loss of its anti-inflammatory function.