کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2048791 1074100 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mast cell signaling: The role of protein tyrosine kinase Syk, its activation and screening methods for new pathway participants
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Mast cell signaling: The role of protein tyrosine kinase Syk, its activation and screening methods for new pathway participants
چکیده انگلیسی

The aggregation by antigen of the IgE bound to its high affinity receptor on mast cells initiates a complex series of biochemical events that result in the release of inflammatory mediators. The essential role of the protein tyrosine kinase Syk has been appreciated for some time, and newer results have defined the mechanism of its activation. The use of siRNA has defined the relative contribution of Syk, Fyn and Gab2 to signaling and has made possible a screening study to identify previously unrecognized molecules that are involved in these pathways.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 24, 15 December 2010, Pages 4933–4940
نویسندگان
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