کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2048878 | 1074104 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Adrenomedullin protects against hypoxia/reoxygenation-induced cell death by suppression of reactive oxygen species via thiol redox systems
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کلمات کلیدی
CRLR, calcitonin receptor-like receptorADM, adrenomedullin - ADM، adrenomedullinDAPI, 4?-6-diamidino-2-phenylindole - DAPI، 4 -6-diamidino-2-phenylindoleFITC, fluorescein isothiocyanate - فلوئورسین ایسوتیوسیاناتGSH, glutathione - گلوتاتیونGR, glutathione reductase - گلوتاتیون ردوکتازGPX, glutathione peroxidase - گلوتاتیون پراکسیداز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Adrenomedullin protects against hypoxia/reoxygenation-induced cell death by suppression of reactive oxygen species via thiol redox systems Adrenomedullin protects against hypoxia/reoxygenation-induced cell death by suppression of reactive oxygen species via thiol redox systems](/preview/png/2048878.png)
چکیده انگلیسی
Adrenomedullin (ADM) functions as a survival factor against hypoxic cell death. However, molecular mechanisms underlying the cell survival pathway remain largely unknown. In this report, we showed that ADM suppressed reactive oxygen species (ROS) increase by inhibiting reduction of glutathione (GSH) level in hypoxia/reoxygenation (H/R) injury, and increased the activities of glutathione peroxidase and reductase. In addition, ADM maintained total and active reduced thioredoxin (Trx) levels against H/R. We also found that ADM blocked nuclear translocation of Trx induced by H/R. The results of the present study show that ADM regulates cellular ROS levels via the GSH and Trx system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 1, 4 January 2010, Pages 213–218
Journal: FEBS Letters - Volume 584, Issue 1, 4 January 2010, Pages 213–218
نویسندگان
Su-Mi Kim, Jee-Youn Kim, Sun Lee, Jae-Hoon Park,