کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2049299 1074123 2010 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
On the biogenesis of myelin membranes: Sorting, trafficking and cell polarity
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
On the biogenesis of myelin membranes: Sorting, trafficking and cell polarity
چکیده انگلیسی

In the central nervous system, a multilayered membrane layer known as the myelin sheath enwraps axons, and is required for optimal saltatory signal conductance. The sheath develops from membrane processes that extend from the plasma membrane of oligodendrocytes and displays a unique lipid and protein composition. Myelin biogenesis is carefully regulated, and multiple transport pathways involving a variety of endosomal compartments are involved. Here we briefly summarize how the major myelin proteins proteolipid protein and myelin basic protein reach the sheath, and highlight potential mechanisms involved, including the role of myelin specific lipids and cell polarity related transport pathways.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 9, 3 May 2010, Pages 1760–1770
نویسندگان
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