کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2049584 | 1074133 | 2007 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mouse Prickle1 and Prickle2 are expressed in postmitotic neurons and promote neurite outgrowth
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Mouse Prickle1 and Prickle2 are expressed in postmitotic neurons and promote neurite outgrowth Mouse Prickle1 and Prickle2 are expressed in postmitotic neurons and promote neurite outgrowth](/preview/png/2049584.png)
چکیده انگلیسی
The Drosophila planar cell polarity (PCP) gene prickle has been previously indicated as one of the regulators of gastrulation in the early embryonic stage. However, the functional role of prickle in the brain in particular is not known. We first indicated that mouse Prickle1 and Prickle2 are continually expressed in the brain throughout the embryonic stages and are observed to be specifically expressed in the postmitotic neurons. Furthermore, Prickle1 or Prickle2 depletion effectively decreases the neurite outgrowth levels of mouse neuroblastoma Neuro2a cells. These results indicate that mouse Prickle1 and Prickle2 possibly regulate positive neurite formation during brain development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 24, 2 October 2007, Pages 4754–4760
Journal: FEBS Letters - Volume 581, Issue 24, 2 October 2007, Pages 4754–4760
نویسندگان
Hiroaki Okuda, Shingo Miyata, Yasutake Mori, Masaya Tohyama,