کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2049663 1074137 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Time-dependent regulation of muscle caveolin activation and insulin signalling in response to high-fat diet
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Time-dependent regulation of muscle caveolin activation and insulin signalling in response to high-fat diet
چکیده انگلیسی

We studied the effect of high-fat diet on the expression and activation of the three caveolins in rat skeletal muscle and their association with the insulin signalling cascade. Initial response was characterized by increased signalling through Cav-1 and Cav-3 phosphorylation, suggesting that both participate in an initial acute response to the calorie surplus. Afterwards, Cav-1 signalling was slightly reduced, whereas Cav-3 remained active. Late chronic phase signalling through both proteins was impaired inducing a prediabetic state. Summarizing, caveolins seem to mediate a time-dependent regulation of insulin cascade in response to high-fat diet in muscle.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 583, Issue 19, 6 October 2009, Pages 3259–3264
نویسندگان
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