کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2049832 | 1074144 | 2008 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
PEG10 directly regulated by E2Fs might have a role in the development of hepatocellular carcinoma
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: PEG10 directly regulated by E2Fs might have a role in the development of hepatocellular carcinoma PEG10 directly regulated by E2Fs might have a role in the development of hepatocellular carcinoma](/preview/png/2049832.png)
چکیده انگلیسی
PEG10 is an imprinted gene which is up-regulated in hepatocelluar carcinoma (HCC). However, the mechanism of PEG10 regulation remains to be elucidated. In this work the transcription factors E2F-1 and -4 were demonstrated to bind directly to the promoter of PEG10 and thereby regulate its expression. The expression profile of HCC tissues also suggested E2Fs were involved in PEG10 regulation. Further functional analysis showed that PEG10 was involved in the repression of apoptosis induced by serum deprivation and chemotherapeutic drugs. These findings link cancer genetics and epigenetics by showing that E2F acts directly upstream of an anti-apoptosis imprinted gene, PEG10.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 582, Issue 18, 6 August 2008, Pages 2793–2798
Journal: FEBS Letters - Volume 582, Issue 18, 6 August 2008, Pages 2793–2798
نویسندگان
Chaochen Wang, Ying Xiao, Zhonghua Hu, Yibin Chen, Na Liu, Gengxi Hu,