کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2049852 1543462 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Circadian expression of FGF21 is induced by PPARα activation in the mouse liver
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Circadian expression of FGF21 is induced by PPARα activation in the mouse liver
چکیده انگلیسی

Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor that regulates the expression of genes associated with lipid metabolism. Recent studies have suggested that the expression of PPARα-dependent fibroblast growth factor 21 (FGF21) plays important roles in adaptation to fasting, such as lipolysis and ketogenesis. We found that a nighttime injection of bezafibrate, a ligand of PPARα, effectively induced FGF21 expression, whereas a daytime injection did not affect it. Furthermore, bezafibrate-induced circadian FGF21 expression was abolished in PPARα-deficient mice. These observations suggest that bezafibrate-induced circadian FGF21 expression is due to circadian variations in the responsiveness of the PPARα system in the liver.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 582, Issues 25–26, 29 October 2008, Pages 3639–3642
نویسندگان
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